Painkillers are responsible for causing severe long-lasting pain, CU research team unveils

The overdosing of painkillers can cause severe harm in health. A recent research has unveiled that painkiller abuse, overdosing, and addiction often force abuser in enduring serious physical harm. The study was conducted for three months by University of Colorado. The study result highlighted that an increase use of morphine caused chronic pain in lab rats. The researchers alerted that people who are overdosing painkillers will suffer similar fate.

The research was conducted by a team of researcher from CU. Assistant research professor Peter Grace and Professor Linda Watkins conducted the research. The study emphasizes that lab rats displayed enduring physical pain after going through repeated uses of morphine for five consecutive days. . Professor Grace stated “Our key finding is that we were able to demonstrate that a brief treatment with a pain killer, like morphine, doubled the duration of chronic pain,”. Professor Grace works for the University of Colorado at department of psychology and neuroscience.

The research findings were published in the “Proceedings of the National Academy of Sciences,” . The research discoveries created an instant uproar because Morphine is an extremely common medicine and the use of it has been widespread because of availability and usefulness. The study results specially showed that uses of Morphine escalated release of pain signals from specific immune cells. This specific signal also protracted lasting pain in rats. Researchers also revealed that a nerve injury in the rats would send notifications from nerve cells to the spinal cord and put them in “alert mode.”

Researchers then tried to treat the injuries with painkillers like morphine.  Surprisingly when the cells went into an overdrive and triggered a “cascade of actions,” such as spinal cord inflammation, Rats were enduring severe physical pain. The research team also identified the combination of the initial pain signals combined with morphine increased pain-responsive nerve cell activity in the spinal cord and brain. The findings were that the initial symptoms turned in to increased pain that could last for several months.

Professor Warkins said “The implications for people taking opioids like morphine, oxycodone and methadone are great, since we show the short-term decision to take such opioids can have devastating consequences of making pain worse and longer lasting, this is a very ugly side to opioids that had not been recognized before.” According to the reports of National Institute on Drug Abuse, the number of American died of opiod overdose rises from 6000 to 20000 only in 2014.


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